Mistranslation of the genetic code

FEBS Lett. 2014 Nov 28;588(23):4305-10. doi: 10.1016/j.febslet.2014.08.035. Epub 2014 Sep 16.


During mRNA decoding at the ribosome, deviations from stringent codon identity, or "mistranslation," are generally deleterious and infrequent. Observations of organisms that decode some codons ambiguously, and the discovery of a compensatory increase in mistranslation frequency to combat environmental stress have changed the way we view "errors" in decoding. Modern tools for the study of the frequency and phenotypic effects of mistranslation can provide quantitative and sensitive measurements of decoding errors that were previously inaccessible. Mistranslation with non-protein amino acids, in particular, is an enticing prospect for new drug therapies and the study of molecular evolution.

Keywords: Amino acid; Mistranslation; Protein synthesis; Quality control; Translation; tRNA.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cells / metabolism
  • Codon / genetics
  • Evolution, Molecular
  • Genetic Code / genetics*
  • Humans
  • Mass Spectrometry
  • Protein Biosynthesis / genetics*


  • Codon