Organizing knowledge to enable personalization of medicine in cancer

Genome Biol. 2014 Aug 27;15(8):438. doi: 10.1186/s13059-014-0438-7.


Interpretation of the clinical significance of genomic alterations remains the most severe bottleneck preventing the realization of personalized medicine in cancer. We propose a knowledge commons to facilitate collaborative contributions and open discussion of clinical decision-making based on genomic events in cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genomics
  • Humans
  • Neoplasms / genetics*
  • Neoplasms / therapy
  • Precision Medicine*
  • Software
  • Translational Medical Research / methods*