Anti-N-methyl-D-aspartate receptor encephalitis with positive serum antithyroid antibodies, IgM antibodies against mycoplasma pneumoniae and human herpesvirus 7 PCR in the CSF

Pediatr Infect Dis J. 2014 Aug;33(8):882-3. doi: 10.1097/INF.0000000000000408.


We report the case of a boy with an encephalopathy associated with extrapyramidal and psychiatric symptoms and anti-N-methyl-D-aspartate receptor antibodies. He had positive serum antithyroid antibodies, IgM antibodies against Mycoplasma pneumoniae and human herpesvirus 7 polymerase chain reaction in the cerebrospinal fluid. He was successfully treated with rituximab, after steroids, intravenous immunoglobulin and plasma exchange. The pathophysiology of this disorder may be post-infectious and autoimmune.

Publication types

  • Case Reports

MeSH terms

  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis / drug therapy
  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis / immunology
  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis / microbiology*
  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis / virology
  • Antibodies, Bacterial / cerebrospinal fluid*
  • Antibodies, Monoclonal, Murine-Derived / therapeutic use
  • Antibodies, Viral / cerebrospinal fluid*
  • Autoantibodies / blood*
  • Child
  • Herpesvirus 7, Human / immunology*
  • Humans
  • Immunoglobulin M / cerebrospinal fluid*
  • Immunologic Factors / therapeutic use
  • Male
  • Mycoplasma pneumoniae / immunology*
  • Rituximab


  • Antibodies, Bacterial
  • Antibodies, Monoclonal, Murine-Derived
  • Antibodies, Viral
  • Autoantibodies
  • Immunoglobulin M
  • Immunologic Factors
  • Rituximab