Cancer genomics: one cell at a time

Genome Biol. 2014 Aug 30;15(8):452. doi: 10.1186/s13059-014-0452-9.


The study of single cancer cells has transformed from qualitative microscopic images to quantitative genomic datasets. This paradigm shift has been fueled by the development of single-cell sequencing technologies, which provide a powerful new approach to study complex biological processes in human cancers.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell-Free System*
  • Clonal Evolution
  • Genome, Human
  • Genomics / methods*
  • Humans
  • Neoplasms / genetics*