Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine

Genome Biol. 2014 Aug 27;15(8):453. doi: 10.1186/s13059-014-0453-8.


The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers, Tumor / agonists*
  • Biomarkers, Tumor / genetics*
  • Clonal Evolution
  • Genetic Heterogeneity*
  • Humans
  • Neoplasms / genetics*
  • Precision Medicine*


  • Biomarkers, Tumor