Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. Mar-Apr 2015;60(2):106-14.
doi: 10.1016/j.survophthal.2014.07.003. Epub 2014 Aug 12.

Dengue Eye Disease

Affiliations
Review

Dengue Eye Disease

Aaron W Ng et al. Surv Ophthalmol. .

Abstract

Dengue fever, a viral disease epidemic in some parts of the world, is of considerable international concern, with a growing incidence owing to developing urbanization, tourism, and trade. Ocular manifestations of dengue fever are uncommon, but of great significance. Proposed mechanisms include direct viral infection as well as immunologic phenomena. Common manifestations include subconjunctival, vitreous, and retinal hemorrhages; posterior uveitis; optic neuritis; and maculopathies such as foveolitis, hemorrhage, and edema. Main symptoms include blurring of vision, scotomata, metamorphopsia, and floaters. Diagnostic and monitoring investigations described included optical coherence tomography, fundus fluorescein and indocyanine green angiography, visual field analysis, and electrophysiologic tests. Management is based on clinical presentation and includes active surveillance as well as various anti-inflammatory and immunosuppressive therapies. There have been no prospective, randomized therapeutic trials, and it is unclear if the disease is self-limiting or if treatment is actually beneficial. Prognosis varies, ranging from full resolution to permanent vision loss despite intervention.

Keywords: chorioretinitis; complications; dengue; foveolitis; hemorrhage; infection; macular edema; maculopathy; optic neuritis; uveitis; viral.

Similar articles

  • Ophthalmologic aspects of chikungunya infection.
    Martínez-Pulgarín DF, Chowdhury FR, Villamil-Gomez WE, Rodriguez-Morales AJ, Blohm GM, Paniz-Mondolfi AE. Martínez-Pulgarín DF, et al. Travel Med Infect Dis. 2016 Sep-Oct;14(5):451-457. doi: 10.1016/j.tmaid.2016.05.008. Epub 2016 May 26. Travel Med Infect Dis. 2016. PMID: 27238905 Review.
  • Optical coherence tomography patterns as predictors of visual outcome in dengue-related maculopathy.
    Teoh SC, Chee CK, Laude A, Goh KY, Barkham T, Ang BS; Eye Institute Dengue-related Ophthalmic Complications Workgroup. Teoh SC, et al. Retina. 2010 Mar;30(3):390-8. doi: 10.1097/IAE.0b013e3181bd2fc6. Retina. 2010. PMID: 20094013
  • Ocular manifestations in Dengue fever.
    Siqueira RC, Vitral NP, Campos WR, Oréfice F, de Moraes Figueiredo LT. Siqueira RC, et al. Ocul Immunol Inflamm. 2004 Dec;12(4):323-7. doi: 10.1080/092739490500345. Ocul Immunol Inflamm. 2004. PMID: 15621872
  • Ocular manifestations of dengue fever.
    Lim WK, Mathur R, Koh A, Yeoh R, Chee SP. Lim WK, et al. Ophthalmology. 2004 Nov;111(11):2057-64. doi: 10.1016/j.ophtha.2004.03.038. Ophthalmology. 2004. PMID: 15522372
  • Ocular manifestations of dengue.
    Somkijrungroj T, Kongwattananon W. Somkijrungroj T, et al. Curr Opin Ophthalmol. 2019 Nov;30(6):500-505. doi: 10.1097/ICU.0000000000000613. Curr Opin Ophthalmol. 2019. PMID: 31503074 Review.
See all similar articles

Cited by 19 articles

See all "Cited by" articles

MeSH terms

Substances

LinkOut - more resources

Feedback