Adult neural stem cells stake their ground

Trends Neurosci. 2014 Oct;37(10):563-71. doi: 10.1016/j.tins.2014.08.006. Epub 2014 Sep 12.


The birth of new neurons in the walls of the adult brain lateral ventricles has captured the attention of many neuroscientists for over 2 decades, yielding key insights into the identity and regulation of neural stem cells (NSCs). In the adult ventricular-subventricular zone (V-SVZ), NSCs are a specialized form of astrocyte that generates several types of neurons for the olfactory bulb. In this review, we discuss recent findings regarding the unique organization of the V-SVZ NSC niche, the multiple regulatory controls of neuronal production, the distinct regional identities of adult NSCs, and the epigenetic mechanisms that maintain adult neurogenesis. Understanding how V-SVZ NSCs establish and maintain lifelong neurogenesis continues to provide surprising insights into the cellular and molecular regulation of neural development.

Keywords: chromatin; epigenetics; neural stem cell; neurogenesis; neurotransmitter; niche; regional identity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adult Stem Cells / physiology*
  • Animals
  • Epigenesis, Genetic / physiology*
  • Neural Stem Cells / physiology*
  • Neurogenesis / physiology*
  • Stem Cell Niche / physiology*