Harmonized benchmark labels of the hippocampus on magnetic resonance: the EADC-ADNI project

Alzheimers Dement. 2015 Feb;11(2):151-60.e5. doi: 10.1016/j.jalz.2013.12.019. Epub 2014 Sep 13.


Background: A globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Our aim was to produce benchmark labels based on the HarP for manual segmentation.

Methods: Five experts of manual hippocampal segmentation underwent specific training on the HarP and segmented 40 right and left hippocampi from 10 ADNI subjects on both 1.5 T and 3 T scans. An independent expert visually checked segmentations for compliance with the HarP. Descriptive measures of agreement between tracers were intraclass correlation coefficients (ICCs) of crude volumes and similarity coefficients of three-dimensional volumes.

Results: Two hundred labels have been provided for the 20 magnetic resonance images. Intra- and interrater ICCs were >0.94, and mean similarity coefficients were 1.5 T, 0.73 (95% confidence interval [CI], 0.71-0.75); 3 T, 0.75 (95% CI, 0.74-0.76).

Conclusion: Certified benchmark labels have been produced based on the HarP to be used for tracers' training and qualification.

Keywords: ADNI; Alzheimer's disease; Anatomic landmark; Harmonization; Harmonized protocol; Hippocampal atrophy; Hippocampal volume; Hippocampus; MRI; Manual tracing; Medial temporal lobes; Neuroimaging; Standard operating procedures.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / pathology
  • Atrophy
  • Cognitive Dysfunction / pathology
  • Female
  • Hippocampus / anatomy & histology
  • Hippocampus / pathology*
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods
  • Inservice Training / methods
  • Magnetic Resonance Imaging / instrumentation
  • Magnetic Resonance Imaging / methods*
  • Male
  • Neuroimaging / methods*
  • Organ Size
  • Reproducibility of Results