Common mechanisms activate plant guard receptors and TLR4

Trends Immunol. 2014 Oct;35(10):454-6. doi: 10.1016/ Epub 2014 Sep 12.


In metazoans, the innate immune system uses Pattern Recognition Receptors to detect conserved microbial products, whereas in plants Guard Receptors detect virulence factors or activities encoded by pathogens. In a recent study, Williams and colleagues report that plant Guard receptors can be activated by a mechanism remarkably similar to that of mammalian Toll-like Receptor 4.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Arabidopsis / immunology*
  • Arabidopsis Proteins / chemistry*
  • Plant Proteins / chemistry*
  • Receptors, Immunologic / chemistry*


  • Arabidopsis Proteins
  • Plant Proteins
  • Receptors, Immunologic