Developmental origins of health and disease--global public health implications

Best Pract Res Clin Obstet Gynaecol. 2015 Jan;29(1):24-31. doi: 10.1016/j.bpobgyn.2014.06.007. Epub 2014 Aug 19.


The rapidly rising prevalence of non-communicable diseases (NCDs) represents a major challenge to public health and clinical medicine globally. NCDs are increasing rapidly in high-income countries, but even more rapidly in some low-middle-income countries with insufficient resources to meet the challenge. Whilst not identified in the Millennium Development Goals, there is much attention paid to NCDs in the discussions at many levels on the Sustainable Development Goals, as they underpin economic, social and environmental development in the post-2015 era. In this article, we discuss how a life-course approach to health, commencing of necessity in early development, can provide new opportunities for addressing this challenge. The approach can leverage human health capital throughout life and across generations. New insights into mechanisms, especially those processes by which the developmental environment affects epigenetic processes in the developing offspring, offer the prospect of identifying biomarkers of future risks. New interventions to promote health literacy, lifestyle and physical fitness in adolescents, young adults and their children hold great promise. In this respect, health-care professionals concerned with preconceptional, pregnancy and newborn care will have a vital role to play.

Keywords: epigenetic; health literacy; non-communicable disease.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / prevention & control*
  • Chronic Disease
  • Diabetes Mellitus / etiology
  • Diabetes Mellitus / prevention & control*
  • Epigenesis, Genetic
  • Female
  • Global Health
  • Health Policy
  • Health Promotion / methods*
  • Humans
  • Life Style
  • Maternal Health Services / methods*
  • Obesity / etiology
  • Obesity / prevention & control*
  • Pregnancy
  • Pregnancy Complications / etiology
  • Pregnancy Complications / prevention & control
  • Prenatal Exposure Delayed Effects / etiology
  • Prenatal Exposure Delayed Effects / prevention & control*
  • Public Health
  • Risk Factors