Neuromuscular and cardiovascular effects of doxacurium in children anaesthetized with halothane

Br J Anaesth. 1989 Mar;62(3):263-8. doi: 10.1093/bja/62.3.263.

Abstract

The neuromuscular and cardiovascular effects of doxacurium chloride (BW A938U) were evaluated in 27 children (2-12 yr) anaesthetized with 1% halothane and nitrous oxide in oxygen. In nine children the incremental technique was used to establish a cumulative dose-response curve by train-of-four stimulation. The remaining children received either 30 or 50 micrograms kg-1 of the drug as a single bolus. The median ED50 and ED95 of doxacurium in children were 19 and 32 micrograms kg-1, respectively. No clinically significant change in heart rate or arterial pressure occurred. Following doxacurium 30 micrograms kg-1 and 50 micrograms kg-1, recovery to 25% of control occurred in 25 (SEM 6) and 44 (3) min, respectively. The recovery index (25-75% of control) was 27 (2) min. The duration of action of doxacurium is similar to that of tubocurarine and dimethyl-tubocurarine in children. Compared with adults, children seem to require more doxacurium (microgram kg-1) to achieve a comparable degree of neuromuscular depression, and they recover more rapidly.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anesthesia Recovery Period
  • Blood Pressure / drug effects
  • Child
  • Child, Preschool
  • Dose-Response Relationship, Drug
  • Halothane*
  • Heart Rate / drug effects
  • Hemodynamics / drug effects*
  • Humans
  • Isoquinolines / adverse effects
  • Isoquinolines / pharmacology*
  • Neuromuscular Junction / drug effects*
  • Neuromuscular Nondepolarizing Agents / adverse effects
  • Neuromuscular Nondepolarizing Agents / pharmacology*
  • Time Factors

Substances

  • Isoquinolines
  • Neuromuscular Nondepolarizing Agents
  • doxacurium
  • Halothane