Long-term utility and durability of the therapeutic effects of bimatoprost 0.03% for eyelash augmentation in healthy Asian subjects

Dermatology. 2014;229(3):222-9. doi: 10.1159/000363379. Epub 2014 Sep 6.

Abstract

Background: Eyelashes of Asians differ from those of Caucasians in morphology and growth characteristics. Ethnic differences also exist for the tolerability profile of prostaglandin analogues.

Objective: To evaluate the long-term utility and durability of bimatoprost 0.03% in eyelash augmentation in Asian females.

Methods: One cohort received bimatoprost 0.03% for 36 weeks and another for 20 weeks, with the latter cohort followed for 16 weeks after treatment cessation. The primary endpoint was the percent change in eyelash length at week 20. Secondary measures included percent change in eyelash thickness and darkness, physician's Global Eyelash Assessment and patient satisfaction.

Results: At week 20, eyelash length was enhanced in a time-dependent manner, with maximum improvement achieved (19.3%; p < 0.0001). Significant improvements in thickness and darkness were also achieved (22.9%, 6.0%; p < 0.0001). 77.8% of subjects improved by ≥1 grade on Global Eyelash Assessment, with 83.1% satisfied/very satisfied. Improvements were maintained with ongoing treatment to 36 weeks, while these effects were progressively lost with discontinuation.

Conclusion: Bimatoprost 0.03% safely enhanced eyelashes in Asian females, maintained with ongoing treatment. Cessation of treatment was associated with progressive loss of effects.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adult
  • Amides / administration & dosage*
  • Analysis of Variance
  • Asian Continental Ancestry Group / statistics & numerical data*
  • Bimatoprost
  • Cloprostenol / administration & dosage
  • Cloprostenol / analogs & derivatives*
  • Cohort Studies
  • Cosmetic Techniques
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Esthetics
  • Eyelashes / drug effects*
  • Eyelashes / growth & development*
  • Female
  • Humans
  • Long-Term Care
  • Patient Safety
  • Patient Satisfaction / statistics & numerical data
  • Prospective Studies
  • Singapore

Substances

  • Amides
  • Cloprostenol
  • Bimatoprost