DruGeVar: an online resource triangulating drugs with genes and genomic biomarkers for clinical pharmacogenomics

Public Health Genomics. 2014;17(5-6):265-71. doi: 10.1159/000365895. Epub 2014 Sep 9.


Background/aims: Pharmacogenomics aims to rationalize drug use by minimizing drug toxicity and/or by increasing drug efficacy. A large number of genomic markers have been correlated with variable drug responses and severity of adverse drug reactions. Although a number of these drugs bear pharmacogenomic information in their labels--approved by regulatory agencies--and comprehensive drug/gene lists exist online, information related to the respective pharmacogenomic biomarkers is currently missing from such lists.

Methods: We extracted information from the published literature and online resources and developed DruGeVar (http://drugevar.genomicmedicinealliance.org), an online resource triangulating drugs with genes and pharmacogenomic biomarkers in an effort to build a comprehensive database that could serve clinical pharmacogenomics.

Results and conclusions: A user-friendly data querying and visualization interface allows users to formulate simple and complex queries. Such a database would be readily applicable as a stand-alone resource or a plug-in module for other databases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Databases, Factual*
  • Drug-Related Side Effects and Adverse Reactions / genetics*
  • Genetic Markers
  • Genomics
  • Humans
  • Internet
  • Online Systems
  • Pharmacogenetics*
  • Software*


  • Genetic Markers