Assisted reproductive technology in SLE and APS

Lupus. 2014 Oct;23(12):1239-41. doi: 10.1177/0961203314527370.


Assisted reproductive technology (ART) procedures, which include in vitro fertilization (IVF), are performed frequently and may be considered for patients with systemic lupus erythematosus and antiphospholipid syndrome. These procedures do not appear to increase the risk of disease flare or thrombosis in these patients. In addition, the presence of antiphospholipid antibodies (aPL) does not independently predict the outcome of IVF pregnancies. As with pregnancies that are achieved naturally, candidates for ART should have quiescent disease for at least 6 months prior to attempting pregnancy for the best possible outcome for mother and child.

Keywords: Antiphospholipid syndrome; anticardiolipin antibodies; lupus anticoagulant; pregnancy; systemic lupus erythematosus.

MeSH terms

  • Antibodies, Antiphospholipid / blood
  • Antiphospholipid Syndrome / complications*
  • Female
  • Humans
  • Infertility, Female / etiology
  • Lupus Erythematosus, Systemic / complications*
  • Pregnancy
  • Reproductive Techniques, Assisted* / adverse effects


  • Antibodies, Antiphospholipid