Cardiac allograft prolongation in mice treated with combined posttransplantation total-lymphoid irradiation and anti-L3T4 antibody therapy

Transplantation. 1989 Apr;47(4):587-91. doi: 10.1097/00007890-198904000-00004.

Abstract

Neonatal cardiac allograft survival was examined in mice treated with anti-L3T4 antibody, posttransplantation total lymphoid irradiation (TLI) or a combination of both therapies. Independently, both posttransplantation TLI and short-course antibody treatment allowed minimal prolongation. However, synergistic prolongation in graft survival was observed with the combination (synergistic) therapy. Fluorescence-activated cell sorter analysis of peripheral blood lymphocytes from animals treated with combined anti-L3T4 and posttransplantation TLI additionally revealed "synergy" with respect to the degree of peripheral lymphocyte depletion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / therapeutic use*
  • Antigens, Differentiation, T-Lymphocyte / immunology*
  • Antigens, Ly / immunology
  • Combined Modality Therapy
  • Graft Survival*
  • Heart Transplantation*
  • Immunosuppression / methods*
  • Lymphatic System / radiation effects*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • T-Lymphocytes, Regulatory / immunology
  • Transplantation, Homologous

Substances

  • Antibodies, Monoclonal
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Ly