No evidence for genetic assortative mating beyond that due to population stratification

doi:10.1073/pnas.1410781111

Comment

. 2014 Oct 7;111(40):E4137.

doi: 10.1073/pnas.1410781111. Epub 2014 Sep 17.

No evidence for genetic assortative mating beyond that due to population stratification

Abdel Abdellaoui¹, Karin J H Verweij², Brendan P Zietsch³

Affiliations

¹ Department of Biological Psychology, Vrije Universiteit Amsterdam, 1081 BT, Amsterdam, The Netherlands;
² Department of Biological Psychology, Vrije Universiteit Amsterdam, 1081 BT, Amsterdam, The Netherlands; School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD 4029, Australia; and.
³ School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD 4029, Australia; and Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD 4006, Australia zietsch@psy.uq.edu.au.

PMID: 25232036
PMCID: PMC4210009
DOI: 10.1073/pnas.1410781111

Comment

No evidence for genetic assortative mating beyond that due to population stratification

Abdel Abdellaoui et al. Proc Natl Acad Sci U S A. 2014.

. 2014 Oct 7;111(40):E4137.

doi: 10.1073/pnas.1410781111. Epub 2014 Sep 17.

Authors

Abdel Abdellaoui¹, Karin J H Verweij², Brendan P Zietsch³

Affiliations

¹ Department of Biological Psychology, Vrije Universiteit Amsterdam, 1081 BT, Amsterdam, The Netherlands;
² Department of Biological Psychology, Vrije Universiteit Amsterdam, 1081 BT, Amsterdam, The Netherlands; School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD 4029, Australia; and.
³ School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD 4029, Australia; and Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD 4006, Australia zietsch@psy.uq.edu.au.

PMID: 25232036
PMCID: PMC4210009
DOI: 10.1073/pnas.1410781111

No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Fig. 1.**
The first two ancestry-informative PCs from the PC analysis (PCA) conducted on the European populations from the 1000 Genomes project using Eigenstrat (4). (*Left*) PCs from a PCA on 1,185,924 of the 1,250,013 ancestry SNPs that correlated significantly (α = 0.05) with any of the first five PCs from Domingue et al. (*Right*) PCs from the PCA on 433,450 of 457,201 SNPs that were not individually significantly associated with any of the first five PCs, showing very little evidence of population stratification according to Domingue et al. PC1 correlates 0.97 between the two SNP sets, and PC2 correlates 0.92.

See this image and copyright information in PMC

Comment in

Reply to Abdellaoui et al.: Interpreting GAM.
Domingue BW, Fletcher JM, Conley D, Boardman JD. Domingue BW, et al. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4138. doi: 10.1073/pnas.1413105111. Epub 2014 Sep 17. Proc Natl Acad Sci U S A. 2014. PMID: 25232035 Free PMC article. No abstract available.

Comment on

Genetic and educational assortative mating among US adults.
Domingue BW, Fletcher J, Conley D, Boardman JD. Domingue BW, et al. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):7996-8000. doi: 10.1073/pnas.1321426111. Epub 2014 May 19. Proc Natl Acad Sci U S A. 2014. PMID: 24843128 Free PMC article.

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Assortative mating on blood type: Evidence from one million Chinese pregnancies.
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The social genome of friends and schoolmates in the National Longitudinal Study of Adolescent to Adult Health.
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Assortative Mating-A Missing Piece in the Jigsaw of Psychiatric Genetics.
Plomin R, Krapohl E, O'Reilly PF. Plomin R, et al. JAMA Psychiatry. 2016 Apr;73(4):323-4. doi: 10.1001/jamapsychiatry.2015.3204. JAMA Psychiatry. 2016. PMID: 26914795 Free PMC article.
Reply to Abdellaoui et al.: Interpreting GAM.
Domingue BW, Fletcher JM, Conley D, Boardman JD. Domingue BW, et al. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4138. doi: 10.1073/pnas.1413105111. Epub 2014 Sep 17. Proc Natl Acad Sci U S A. 2014. PMID: 25232035 Free PMC article. No abstract available.

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References

1. Domingue BW, Fletcher J, Conley D, Boardman JD. Genetic and educational assortative mating among US adults. Proc Natl Acad Sci USA. 2014;111(22):7996–8000. - PMC - PubMed
1. Bossard JH. Residential propinquity as a factor in marriage selection. Am J Sociol. 1932;38(2):219–224.
1. Brittingham A, De La Cruz GP. Ancestry: 2000. Washington, DC: US Department of Commerce, Economics and Statistics Administration, US Census Bureau; 2004.
1. Price AL, et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006;38(8):904–909. - PubMed
1. Abdellaoui A, et al. Population structure, migration, and diversifying selection in the Netherlands. Eur J Hum Genet. 2013;21(11):1277–1285. - PMC - PubMed

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[1] Domingue BW, Fletcher J, Conley D, Boardman JD. Genetic and educational assortative mating among US adults. Proc Natl Acad Sci USA. 2014;111(22):7996–8000. - PMC - PubMed

[2] Domingue BW, Fletcher J, Conley D, Boardman JD. Genetic and educational assortative mating among US adults. Proc Natl Acad Sci USA. 2014;111(22):7996–8000. - PMC - PubMed

[3] Bossard JH. Residential propinquity as a factor in marriage selection. Am J Sociol. 1932;38(2):219–224.

[4] Bossard JH. Residential propinquity as a factor in marriage selection. Am J Sociol. 1932;38(2):219–224.

[5] Brittingham A, De La Cruz GP. Ancestry: 2000. Washington, DC: US Department of Commerce, Economics and Statistics Administration, US Census Bureau; 2004.

[6] Brittingham A, De La Cruz GP. Ancestry: 2000. Washington, DC: US Department of Commerce, Economics and Statistics Administration, US Census Bureau; 2004.

[7] Price AL, et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006;38(8):904–909. - PubMed

[8] Price AL, et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006;38(8):904–909. - PubMed

[9] Abdellaoui A, et al. Population structure, migration, and diversifying selection in the Netherlands. Eur J Hum Genet. 2013;21(11):1277–1285. - PMC - PubMed

[10] Abdellaoui A, et al. Population structure, migration, and diversifying selection in the Netherlands. Eur J Hum Genet. 2013;21(11):1277–1285. - PMC - PubMed

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No evidence for genetic assortative mating beyond that due to population stratification

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No evidence for genetic assortative mating beyond that due to population stratification

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Conflict of interest statement

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