The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource

Nucleic Acids Res. 2015 Jan;43(Database issue):D873-8. doi: 10.1093/nar/gku843. Epub 2014 Sep 17.


Multiple studies characterizing the human ageing phenotype have been conducted for decades. However, there is no centralized resource in which data on multiple age-related changes are collated. Currently, researchers must consult several sources, including primary publications, in order to obtain age-related data at various levels. To address this and facilitate integrative, system-level studies of ageing we developed the Digital Ageing Atlas (DAA). The DAA is a one-stop collection of human age-related data covering different biological levels (molecular, cellular, physiological, psychological and pathological) that is freely available online ( Each of the >3000 age-related changes is associated with a specific tissue and has its own page displaying a variety of information, including at least one reference. Age-related changes can also be linked to each other in hierarchical trees to represent different types of relationships. In addition, we developed an intuitive and user-friendly interface that allows searching, browsing and retrieving information in an integrated and interactive fashion. Overall, the DAA offers a new approach to systemizing ageing resources, providing a manually-curated and readily accessible source of age-related changes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging* / genetics
  • Aging* / pathology
  • Aging* / physiology
  • Aging* / psychology
  • Databases, Factual*
  • Humans
  • Internet