Metastatic pancreatic neuroendocrine tumor to the central nervous system in a patient with von Hippel-Lindau disease: A case report and literature review

Br J Neurosurg. 2015 Apr;29(2):291-3. doi: 10.3109/02688697.2014.957650. Epub 2014 Sep 18.

Abstract

Pancreatic neuroendocrine tumor (NET) is frequently encountered in patients with von Hippel-Lindau disease (VHL) and uncommonly metastasizes to the central nervous system. Here, we present the case of a VHL patient with symptomatic pancreatic NET metastases to both the cervical spinal cord and a preexisting brainstem hemangioblastoma (e.g., tumor- to-tumor metastasis).

Keywords: pancreatic neuroendocrine tumor; tumor-to-tumor metastasis; von Hippel–Lindau.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Brain Stem Neoplasms / complications
  • Central Nervous System / pathology
  • Central Nervous System / surgery*
  • Cerebellar Neoplasms / complications
  • Cerebellar Neoplasms / diagnosis
  • Cerebellar Neoplasms / surgery*
  • Hemangioblastoma / complications
  • Hemangioblastoma / pathology
  • Hemangioblastoma / surgery*
  • Humans
  • Male
  • Middle Aged
  • Pancreatic Neoplasms / complications
  • Pancreatic Neoplasms / diagnosis
  • Pancreatic Neoplasms / surgery*
  • von Hippel-Lindau Disease / complications
  • von Hippel-Lindau Disease / diagnosis
  • von Hippel-Lindau Disease / surgery*