Objective: To determine whether endometrial hCG infusion at the time of human blastocyst transfer impacts implantation rates.
Design: Randomized double-blinded placebo-controlled trial.
Patient(s): Infertile couples with the female partner less than 43 years old (n = 300) undergoing fresh or frozen ET of one or two blastocysts.
Intervention(s): Patients undergoing ET were randomized into either a treatment or a control group. The treatment group received an infusion of 500 IU of hCG diluted in ET media. The control group received a sham infusion of ET media. Infusions were done using a separate catheter less than 3 minutes before actual ET.
Main outcome measure(s): Sustained implantation rate: ongoing viable gestation (primary outcome) and ongoing pregnancy rate (secondary outcome).
Result(s): A total of 473 blastocysts were transferred into 300 patients. There were no differences between the two groups in sustained implantation rate (48.1% in the hCG group, 44.2% in the control group) or ongoing pregnancy rate (58.8% in the hCG group, 52.0% in the control group).
Conclusion(s): Endometrial infusion of hCG at the time of blastocyst ET does not improve sustained implantation rates.
Clinical trial registration number: NCT01643993.
Keywords: embryo transfer; hCG; implantation rate; intrauterine hCG; pregnancy rate.
Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.