Finger millet bran supplementation alleviates obesity-induced oxidative stress, inflammation and gut microbial derangements in high-fat diet-fed mice

Br J Nutr. 2014 Nov 14;112(9):1447-58. doi: 10.1017/S0007114514002396. Epub 2014 Sep 19.


Several epidemiological studies have shown that the consumption of finger millet (FM) alleviates diabetes-related complications. In the present study, the effect of finger millet whole grain (FM-WG) and bran (FM-BR) supplementation was evaluated in high-fat diet-fed LACA mice for 12 weeks. Mice were divided into four groups: control group fed a normal diet (10 % fat as energy); a group fed a high-fat diet; a group fed the same high-fat diet supplemented with FM-BR; a group fed the same high-fat diet supplemented with FM-WG. The inclusion of FM-BR at 10 % (w/w) in a high-fat diet had more beneficial effects than that of FM-WG. FM-BR supplementation prevented body weight gain, improved lipid profile and anti-inflammatory status, alleviated oxidative stress, regulated the expression levels of several obesity-related genes, increased the abundance of beneficial gut bacteria (Lactobacillus, Bifidobacteria and Roseburia) and suppressed the abundance of Enterobacter in caecal contents (P≤ 0·05). In conclusion, FM-BR supplementation could be an effective strategy for preventing high-fat diet-induced changes and developing FM-BR-enriched functional foods.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / metabolism
  • Animals
  • Bacterial Load
  • Blood Glucose / metabolism
  • Diet, High-Fat / adverse effects*
  • Dietary Supplements
  • Eleusine*
  • Gene Expression Regulation
  • Inflammation / prevention & control*
  • Intestines / microbiology*
  • Lipids / blood
  • Liver / metabolism
  • Mice
  • Mitochondria, Muscle / metabolism
  • Muscle, Skeletal / metabolism
  • Nutrigenomics
  • Obesity / genetics
  • Obesity / metabolism*
  • Oxidative Stress*
  • Pancreas / metabolism
  • Seeds
  • Weight Gain


  • Blood Glucose
  • Lipids