Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells

Chem Commun (Camb). 2014 Nov 11;50(87):13388-90. doi: 10.1039/c4cc07155g. Epub 2014 Sep 19.

Abstract

Polymer gold nanoshells (PGNs) are prepared by a novel plant-inspired flavonoid surface modification method. The PGNs show dramatic photothermal properties, which can facilitate the endosomal escape and delivery of siRNA into the cytoplasm of cells. Efficient gene silencing has been achieved using siRNA immobilized PGNs, suggesting the potential applications of in vitro gene regulation by an external NIR stimulus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cytoplasm / genetics
  • Cytoplasm / metabolism
  • Flavonoids / chemistry*
  • Flavonoids / metabolism
  • Gene Silencing
  • Gene Transfer Techniques*
  • Gold / chemistry*
  • Gold / metabolism
  • HeLa Cells
  • Humans
  • Metal Nanoparticles / chemistry*
  • Particle Size
  • Photochemical Processes
  • RNA, Small Interfering / genetics*
  • RNA, Small Interfering / metabolism
  • Surface Properties
  • Temperature*

Substances

  • Flavonoids
  • RNA, Small Interfering
  • Gold