Siglec-mediated regulation of immune cell function in disease

Nat Rev Immunol. 2014 Oct;14(10):653-66. doi: 10.1038/nri3737. Epub 2014 Sep 19.

Abstract

All mammalian cells display a diverse array of glycan structures that differ from those that are found on microbial pathogens. Siglecs are a family of sialic acid-binding immunoglobulin-like receptors that participate in the discrimination between self and non-self, and that regulate the function of cells in the innate and adaptive immune systems through the recognition of their glycan ligands. In this Review, we describe the recent advances in our understanding of the roles of Siglecs in the regulation of immune cell function in infectious diseases, inflammation, neurodegeneration, autoimmune diseases and cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Resistance / immunology*
  • Disease Susceptibility / immunology*
  • Humans
  • Immune System / cytology
  • Immune System / immunology*
  • Immune System / metabolism
  • Models, Immunological
  • N-Acetylneuraminic Acid / immunology
  • N-Acetylneuraminic Acid / metabolism
  • Polysaccharides / immunology
  • Polysaccharides / metabolism
  • Protein Binding / immunology
  • Sialic Acid Binding Immunoglobulin-like Lectins / immunology*
  • Sialic Acid Binding Immunoglobulin-like Lectins / metabolism

Substances

  • Polysaccharides
  • Sialic Acid Binding Immunoglobulin-like Lectins
  • N-Acetylneuraminic Acid