Scalable units for building cardiac tissue

Adv Mater. 2014 Nov 12;26(42):7202-8. doi: 10.1002/adma.201403074. Epub 2014 Sep 19.

Abstract

Scalable units for building cardiac tissue are fabricated from biodegradable elastomeric polymers by pairwise stacking of heart-cell scaffolds with sinusoidal internal pore architectures and dedicated perfusable microvessels with rapidly degrading porous interfaces in a parallel flow configuration. This platform supports viable heart cells in vitro and, if validated in vivo, may aid in the regenerative repair of vascularized tissues.

Keywords: heart; microfabrication; polymer; scaffold; vasculature.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Absorbable Implants
  • Animals
  • Cell Adhesion
  • Cell Culture Techniques
  • Cell Enlargement
  • Cell Survival
  • Elastomers / chemistry
  • Heart / physiology*
  • Materials Testing
  • Mechanical Phenomena
  • Microscopy, Electron, Scanning
  • Microvessels / physiology
  • Myocardium / cytology
  • Polymers / chemistry
  • Rats
  • Tissue Engineering / methods*
  • Tissue Scaffolds / chemistry*

Substances

  • Elastomers
  • Polymers