In vitro activity of trospectomycin (U-63366F), a novel spectinomycin analog, against gram-positive isolates from cancer patients

K Rolston; D H Ho; G P Bodey

doi:10.1007/BF01965272

In vitro activity of trospectomycin (U-63366F), a novel spectinomycin analog, against gram-positive isolates from cancer patients

Eur J Clin Microbiol Infect Dis. 1989 Mar;8(3):254-60. doi: 10.1007/BF01965272.

Authors

K Rolston¹, D H Ho, G P Bodey

Affiliation

¹ Department of Medical Specialties, University of Texas M.D. Anderson Cancer Center, Houston 77030.

PMID: 2523806
DOI: 10.1007/BF01965272

Abstract

The in vitro activity of trospectomycin was compared to that of amikacin, cephalothin and vancomycin against gram-positive organisms, mostly isolated from cancer patients. Trospectomycin was considerably more active than amikacin against most isolates tested, particularly species of Staphylococcus and Streptococcus. Overall, vancomycin was the most active agent tested.

Publication types

Comparative Study

MeSH terms

Amikacin / pharmacology
Anti-Bacterial Agents / pharmacology*
Cephalothin / pharmacology
Gram-Positive Bacteria / drug effects*
Gram-Positive Bacteria / isolation & purification
Humans
Neoplasms / microbiology*
Spectinomycin / analogs & derivatives*
Spectinomycin / pharmacology
Staphylococcus / drug effects
Streptococcus / drug effects
Vancomycin / pharmacology

Substances

Anti-Bacterial Agents
trospectomycin
Vancomycin
Amikacin
Spectinomycin
Cephalothin