Cellular and molecular basis of decision-making

EMBO Rep. 2014 Oct;15(10):1023-35. doi: 10.15252/embr.201438993. Epub 2014 Sep 19.

Abstract

People think they are in control of their own decisions: what to eat or drink, whom to marry or pick a fight with, where to live, what to buy. Behavioural economists and neurophysiologists have long studied decision-making behaviours. However, these behaviours have only recently been studied through the light of molecular genetics. Here, we review recent research in mice, Drosophila melanogaster and Caenorhabditis elegans, that analyses the molecular and cellular mechanisms underlying decision-making. These studies interrogate decision-making about food, sexual behaviour, aggression or foraging strategies, and add molecular and cell biology understanding onto the consilience of brain and decision.

Keywords: aggression; decision‐making; nutrient sensing; obesity; sexual behaviour.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / metabolism
  • Brain / physiology
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans / physiology
  • Decision Making / physiology*
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / physiology
  • Feeding Behavior / physiology
  • Humans
  • Mice
  • Sexual Behavior, Animal / physiology