Glucocorticosteroid replacement therapy: a literature review and suggested replacement therapy

Oral Surg Oral Med Oral Pathol. 1989 May;67(5):614-20. doi: 10.1016/0030-4220(89)90285-5.


Administration of exogenous glucocorticosteroids will cause adrenal suppression lasting for up to 12 months; however, the patient's stress response will return within 14 to 30 days. This difference occurs as a result of the effects of corticotropin-releasing factor on the autonomic nervous system and on visceral systems. A new protocol for glucocorticosteroid replacement therapy is proposed that is based on the patient's ability to respond to dental stress.

Publication types

  • Review

MeSH terms

  • Adrenal Glands / drug effects
  • Adrenal Glands / metabolism
  • Dental Care for Disabled*
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / metabolism
  • Glucocorticoids / therapeutic use*
  • Humans
  • Stress, Physiological / physiopathology


  • Glucocorticoids