Short-term efficacy of thyroid hormone supplementation for patients with Down syndrome and low-borderline thyroid function

Am J Ment Retard. 1989 May;93(6):652-6.


The thyroid function of 44 subjects with Down syndrome who were between 2 and 51 years of age was assessed. Three patients (7%) had hypothyroidism, and in 2 of them high titers of antimicrosomal antibody were detected. Seven additional subjects (16%) had low-borderline thyroid function, 6 with elevated thyroid stimulating hormone. These 7 subjects constituted the cohort for an evaluation of the short-term benefits of thyroid hormone supplementation in the low-borderline thyroid functional state. A double-blind crossover drug placebo trial failed to document any cognitive, social, response time, or physical changes attributable to the 8- to 14-week drug treatment period compared to an untreated matched control group. Results provided no evidence for the efficacy of short-term thyroid hormone therapy for this population.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Behavior / drug effects
  • Child
  • Child, Preschool
  • Down Syndrome / complications*
  • Female
  • Humans
  • Hypothyroidism / complications
  • Hypothyroidism / drug therapy*
  • Male
  • Middle Aged
  • Thyroxine / pharmacology*


  • Thyroxine