Non coeliac gluten sensitivity - A new disease with gluten intolerance

Clin Nutr. 2015 Apr;34(2):189-94. doi: 10.1016/j.clnu.2014.08.012. Epub 2014 Aug 29.

Abstract

Until recently gluten intolerance has been believed to be typical of celiac disease (CD) and wheat allergy (WA). In the last few years, however, several study results have been published that have proved that gluten intolerance can also affect people who do not suffer from any of the above mentioned diseases. The new syndrome has been named non-celiac gluten sensitivity (NCGS) or gluten sensitivity (GS). It has been included in the new list of gluten-related disorders published in 2012. Researchers believe that NCGS is the most common syndrome of gluten intolerance. This review discusses many aspects of NCGS epidemiology, pathophysiology, clinical spectrum, and treatment and current tools to identify patients suffering from CD, WA, and NCGS.

Keywords: Celiac disease; Gluten intolerance; Gluten sensitivity; Gluten-free diet; Gluten-related disorders; Non-celiac gluten sensitivity.

Publication types

  • Review

MeSH terms

  • Celiac Disease / diagnosis
  • Diagnosis, Differential
  • Food Hypersensitivity / diagnosis
  • Food Hypersensitivity / epidemiology
  • Food Hypersensitivity / etiology*
  • Food Hypersensitivity / physiopathology
  • Food Hypersensitivity / therapy
  • Gastrointestinal Diseases / diagnosis
  • Gastrointestinal Diseases / epidemiology*
  • Gastrointestinal Diseases / physiopathology*
  • Gastrointestinal Diseases / therapy*
  • Glutens / adverse effects*
  • Humans
  • Wheat Hypersensitivity / diagnosis

Substances

  • Glutens