The action of the collagen-Fe2+ complex at tissular level

Morphol Embryol (Bucur). 1989 Jan-Mar;35(1):59-61.


The aim of this paper is to know the iron dynamics and action of the collagen-Fe2+ complex at tissular level. The results showed that the collagen-Fe2+ complex is biocompatible at tissular level and the ferrous iron entered the animal organism on the well-known metabolic pathways. When a high dose of the complex was administered, an overloading with hemosiderin of macrophages and hepatocytes was noticed.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Collagen / pharmacokinetics
  • Collagen / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Combinations
  • Ferrous Compounds / pharmacokinetics
  • Ferrous Compounds / pharmacology*
  • Hemosiderin / metabolism
  • Male
  • Metalloproteins / pharmacokinetics
  • Metalloproteins / pharmacology*
  • Rats
  • Tissue Distribution


  • Drug Combinations
  • Ferrous Compounds
  • Metalloproteins
  • collagen-ferrous complex
  • ferrous sulfate
  • Collagen
  • Hemosiderin