Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients

Auerkari E I; Joewono V; Handjari D R; Sarwono A T; Suhartono A W; Eto K; Ikeda M A

doi:10.2174/1874210601408010136

Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients

Open Dent J. 2014 Sep 8:8:136-43. doi: 10.2174/1874210601408010136. eCollection 2014.

Authors

Auerkari E I¹, Joewono V², Handjari D R², Sarwono A T³, Suhartono A W³, Eto K⁴, Ikeda M A⁴

Affiliations

¹ Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Salemba Raya 4, Jakarta 10430, Indonesia ; Department of Molecular Craniofacial Embryology, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8549 Japan.
² Department of Anatomic-Pathology, Faculty of Medicine, University of Indonesia, Salemba Raya 6, Jakarta 10430, Indonesia.
³ Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Salemba Raya 4, Jakarta 10430, Indonesia.
⁴ Department of Molecular Craniofacial Embryology, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8549 Japan.

Abstract

Cancer cells exhibit characteristic damage of DNA and its expression. The expression of the tumor suppressors E-cadherin and p27(Kip1) has been tested on 57 head and neck squamous cell carcinomas (HNSCC) of Indonesian subjects. HNSCC tumor samples including both primary and (unrelated) nodal cases were obtained from the archives of Indonesian hospitals, in accordance with acknowledged ethical requirements. Only modest correlation was found between reduced expression of E-cadherin or p27(Kip1) with increased malignancy of primary and nodal growth. The observed strong correlation regardless of malignancy between the expressed levels of E-cadherin and p27(Kip1) suggests that also in combination these would not help to better predict the outcome of HNSCC.

Keywords: E-cadherin; head and neck squamous cell carcinoma; p27Kip1..