Formation of excitation-inhibition balance: inhibition listens and changes its tune

Trends Neurosci. 2014 Oct;37(10):528-30. doi: 10.1016/j.tins.2014.09.001. Epub 2014 Sep 20.


Recently, Xue, Atallah, and Scanziani reported that excitation/inhibition ratios across cortical pyramidal neurons are equalized by activity-dependent modulations of parvalbumin-neuron mediated feedforward inhibition. Their results raise questions about the developmental formation of this excitation-inhibition balance and the potential activity-dependent synaptic plasticity rules that mediate this process.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Female
  • Humans
  • Male
  • Neurons / physiology*
  • Visual Cortex / cytology*
  • Visual Cortex / physiology*