Formation of excitation-inhibition balance: inhibition listens and changes its tune

Huizhong W Tao; Ya-tang Li; Li I Zhang

doi:10.1016/j.tins.2014.09.001

Formation of excitation-inhibition balance: inhibition listens and changes its tune

Trends Neurosci. 2014 Oct;37(10):528-30. doi: 10.1016/j.tins.2014.09.001. Epub 2014 Sep 20.

Authors

Huizhong W Tao¹, Ya-tang Li², Li I Zhang³

Affiliations

¹ Zilkha Neurogenetic Institute, Los Angeles, CA 90089, USA; Department of Cell and Neurobiology, Zilkha Neurogenetic Institute, Los Angeles, CA 90089, USA. Electronic address: htao@usc.edu.
² Zilkha Neurogenetic Institute, Los Angeles, CA 90089, USA.
³ Zilkha Neurogenetic Institute, Los Angeles, CA 90089, USA; Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: liizhang@usc.edu.

Abstract

Recently, Xue, Atallah, and Scanziani reported that excitation/inhibition ratios across cortical pyramidal neurons are equalized by activity-dependent modulations of parvalbumin-neuron mediated feedforward inhibition. Their results raise questions about the developmental formation of this excitation-inhibition balance and the potential activity-dependent synaptic plasticity rules that mediate this process.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Female
Humans
Male
Neurons / physiology*
Visual Cortex / cytology*
Visual Cortex / physiology*

Abstract

Publication types

MeSH terms

Grants and funding