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, 160 (1), 353-8

Identification of Several Clades of Novel Single-Stranded Circular DNA Viruses With Conserved Stem-Loop Structures in Pig Feces

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Identification of Several Clades of Novel Single-Stranded Circular DNA Viruses With Conserved Stem-Loop Structures in Pig Feces

Andrew K Cheung et al. Arch Virol.

Abstract

Metagenomic analysis of fecal samples collected from diarrheal swine detected sequences encoding a replication initiator protein (Rep). The genomes of ten novel single-stranded DNA viruses were determined, and they exhibited a similar genome organization. The two putative open reading frames (ORFs) encoding Rep and the capsid protein are bidirectionally transcribed and separated by two intergenic regions. Stem-loop structure(s) typical of genomes that undergo the rolling-circle DNA replication mechanism were observed. Phylogenetically, these ten genomes are in a monophyletic clade with the previously described porcine stool-associated virus (PoSCV) but are divergent enough to be further classified into to six distinct virus clades.

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