Abstract
Aminoethyl substituted 2-endo-fenchol prepared from (-)-fenchone was used as scaffold for the synthesis of series of 31 amide structures by N-acylation applying cinnamic acids and analogues. The evaluation of their in vitro activity against Mycobacterium tuberculosis H37Rv showed for some of them promising activity-up to 0.2 μg/ml, combined with relatively low cytotoxicity of the selected active compounds.
Keywords:
Amides; Cinnamic acids; Fenchone; Tuberculosis.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acylation
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Amides / chemistry*
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Amino Alcohols / chemistry*
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Antitubercular Agents / chemistry*
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Antitubercular Agents / pharmacology
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Antitubercular Agents / toxicity
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Camphanes
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Cell Survival / drug effects
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Cinnamates / chemistry*
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HEK293 Cells
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Humans
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects
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Norbornanes / chemistry*
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Norbornanes / pharmacology
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Norbornanes / toxicity
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Amides
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Amino Alcohols
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Antitubercular Agents
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Camphanes
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Cinnamates
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Norbornanes
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fenchone
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cinnamic acid