Feasibility and clinical utility of ultra-widefield indocyanine green angiography

Retina. 2015 Mar;35(3):508-20. doi: 10.1097/IAE.0000000000000318.


Purpose: To evaluate the feasibility and clinical utility of a novel noncontact scanning laser ophthalmoscope-based ultra-widefield indocyanine green angiographic system.

Methods: Ultra-widefield indocyanine green angiographic images were captured using a modified Optos P200Tx that produced high-resolution images of the choroidal vasculature with up to a 200° field. Ultra-widefield indocyanine green angiography was performed on patients with a variety of retinal conditions to assess utility of this imaging technique for diagnostic purposes and disease treatment monitoring.

Results: Ultra-widefield indocyanine green angiography was performed on 138 eyes of 69 patients. Mean age was 58 ± 16.9 years (range, 24-85 years). The most common ocular pathologies imaged included central serous chorioretinopathy (24 eyes), uveitis (various subtypes, 16 eyes), age-related macular degeneration (12 eyes), and polypoidal choroidal vasculopathy (4 eyes). In all eyes evaluated with ultra-widefield indocyanine green angiography, high-resolution images of choroidal and retinal circulation were obtained with sufficient detail out to 200° of the fundus.

Conclusion: In this series of 138 eyes, scanning laser ophthalmoscope-based ultra-widefield indocyanine green angiography was clinically practical and provided detailed images of both the central and peripheral choroidal circulation. Future studies are needed to refine the clinical value of this imaging modality and the significance of peripheral choroidal vascular changes in the diagnosis, monitoring, and treatment of ocular diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Choroid / blood supply*
  • Choroid Diseases / diagnosis*
  • Choroid Diseases / physiopathology
  • Coloring Agents*
  • Feasibility Studies
  • Female
  • Fluorescein Angiography / methods*
  • Humans
  • Indocyanine Green*
  • Male
  • Middle Aged
  • Retinal Diseases / diagnosis*
  • Retinal Diseases / physiopathology
  • Retrospective Studies
  • Uveitis / diagnosis*
  • Young Adult


  • Coloring Agents
  • Indocyanine Green