Early visceral pain predicts chronic pain after laparoscopic cholecystectomy

Pain. 2014 Nov;155(11):2400-7. doi: 10.1016/j.pain.2014.09.019. Epub 2014 Sep 22.


Chronic pain after laparoscopic cholecystectomy is related to postoperative pain during the first postoperative week, but it is unknown which components of the early pain response is important. In this prospective study, 100 consecutive patients were examined preoperatively, 1 week postoperatively, and 3, 6, and 12 months postoperatively for pain, psychological factors, and signs of hypersensitivity. Overall pain, incisional pain (somatic pain component), deep abdominal pain (visceral pain component), and shoulder pain (referred pain component) were registered on a 100-mm visual analogue scale during the first postoperative week. Nine patients developed chronic unexplained pain 12 months postoperatively. In a multivariate analysis model, cumulated visceral pain during the first week and number of preoperative biliary pain attacks were identified as independent risk factors for unexplained chronic pain 12 months postoperatively. There were no consistent signs of hypersensitivity in the referred pain area either pre- or postoperatively. There were no significant associations to any other variables examined. The risk of chronic pain after laparoscopic cholecystectomy is relatively low, but significantly related to the visceral pain response during the first postoperative week.

Keywords: Chronic postsurgery pain; Postcholecystectomy pain; Postcholecystectomy syndrome; Referred pain; Visceral pain.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cholecystectomy, Laparoscopic / adverse effects*
  • Chronic Pain / diagnosis*
  • Chronic Pain / etiology
  • Chronic Pain / therapy
  • Cohort Studies
  • Female
  • Humans
  • Hyperalgesia / physiopathology
  • Male
  • Middle Aged
  • Pain, Postoperative / etiology*
  • Pain, Postoperative / psychology
  • Physical Examination
  • Pressure / adverse effects
  • Statistics, Nonparametric
  • Time Factors
  • Vibration / adverse effects
  • Visceral Pain / physiopathology*
  • Young Adult