Anisotropic growth-induced synthesis of dual-compartment Janus mesoporous silica nanoparticles for bimodal triggered drugs delivery

J Am Chem Soc. 2014 Oct 22;136(42):15086-92. doi: 10.1021/ja508733r. Epub 2014 Oct 7.

Abstract

Multifunctional dual-compartment Janus mesoporous silica nanocomposites of UCNP@SiO2@mSiO2&PMO (UCNP = upconversion nanoparticle, PMO = periodic mesoporous organosilica) containing core@shell@shell structured UCNP@SiO2@mSiO2 nanospheres and PMO single-crystal nanocubes have been successfully synthesized via a novel anisotropic island nucleation and growth approach with the ordered mesostructure. The asymmetric Janus nanocomposites show a very uniform size of ~300 nm and high surface area of ~1290 m(2)/g. Most importantly, the Janus nanocomposites possess the unique dual independent mesopores with different pore sizes (2.1 nm and 3.5-5.5 nm) and hydrophobicity/hydrophilicity for loading of multiple guests. The distinct chemical properties of the silica sources and the different mesostructures of the dual-compartments are the necessary prerequisites for the formation of the Janus nanostructure. With the assistance of the near-infrared (NIR) to ultraviolet/visible (UV-vis) optical properties of UCNPs and heat-sensitive phase change materials, the dual-compartment Janus mesoporous silica nanocomposites can be further applied into nanobiomedicine for heat and NIR light bimodal-triggered dual-drugs controllable release. It realizes significantly higher efficiency for cancer cell killing (more than 50%) compared to that of the single-triggered drugs delivery system (~25%).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anisotropy
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology
  • Drug Carriers / chemical synthesis*
  • Drug Carriers / chemistry*
  • HeLa Cells
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Nanocomposites / chemistry*
  • Nanoparticles / chemistry*
  • Nanotechnology / methods*
  • Organosilicon Compounds / chemistry*
  • Porosity
  • Silicon Dioxide / chemistry*

Substances

  • Drug Carriers
  • Organosilicon Compounds
  • Silicon Dioxide
  • Doxorubicin