8-hydroxy-2'-deoxyguanosine and cardiovascular disease: a systematic review

Curr Atheroscler Rep. 2014 Nov;16(11):452. doi: 10.1007/s11883-014-0452-y.


Oxidative stress due to an excess of reactive oxygen species (ROS) may play a role in the development and progression of cardiovascular disease (CVD). 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a marker of oxidative DNA damage caused by ROS. This review aimed to assess the association between 8-OHdG and CVD by reviewing the literature. Studies in human subjects using either plasma or urine to determine 8-OHdG concentrations were surveyed. Eighteen relevant studies were found, of which 13 were case-control studies and five had a prospective design. Without exception, the case-control studies showed significant positive associations between 8-OHdG and CVD. In agreement, two prospective studies showed a significant association of 8-OHdG and heart failure. Furthermore, two prospective studies found a significant association between 8-OHdG and stroke, and finally, one prospective study showed a borderline significant (p = 0.08) association between coronary artery disease (CAD) patients developing a cardiac event and 8-OHdG concentrations. In conclusion, high levels of 8-OHdG in blood and urine are associated with atherosclerosis and heart failure, but further large prospective studies are needed to investigate 8-OHdG as a predictor for cardiovascular diseases.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine
  • Cardiovascular Diseases / drug therapy*
  • Clinical Trials as Topic
  • DNA Damage
  • Deoxyguanosine / analogs & derivatives*
  • Deoxyguanosine / chemistry
  • Deoxyguanosine / therapeutic use
  • Humans
  • Oxidative Stress / drug effects*
  • Reactive Oxygen Species / metabolism*


  • Reactive Oxygen Species
  • 8-Hydroxy-2'-Deoxyguanosine
  • Deoxyguanosine