1 Department of Anaesthesia, Critical Care and Pain Medicine, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, UK lesley.colvin@ed.ac.uk.
2 Department of Anesthesiology and Pain Management, The University of Texas M.D. Anderson Cancer Center, 1400 Holcombe Boulevard Unit 409, Houston, TX 77030, USA.