Hormonal responses to gradual changes in dietary sodium intake in humans

Am J Physiol. 1989 Jun;256(6 Pt 2):R1171-5. doi: 10.1152/ajpregu.1989.256.6.R1171.

Abstract

The effects of gradual (50 mmol/day) increases in dietary sodium intake from 10 to 350 mmol/day on plasma atrial natriuretic peptide (ANP), aldosterone, and plasma renin activity (PRA) were studied in six normal subjects. With the increases in sodium intake there was a progressive increase in urinary sodium from 12.2 +/- 4.4 to 314.8 +/- 31.4 mmol/24 h; plasma ANP increased gradually from 9.9 +/- 1.1 to 23.3 +/- 2.2 pg/ml, with the increases being closely associated with the changes in cumulative sodium balance. Plasma aldosterone decreased significantly from 2,519.7 +/- 147.4 pmol/l on the 10 mmol/day to 1,393.3 +/- 125.4 pmol/l when the sodium intake was increased to 50 mmol/day and decreased further to 251.6 +/- 78.7 pmol/l by the end of the study. The changes in PRA paralleled those in plasma aldosterone with the exception of no significant change in plasma PRA within 24 h of the initial increase in sodium intake. This marked sensitivity in the responses of both the ANP and the renin-aldosterone system to small increases in sodium intake clearly points to their importance in the renal adaptations to alterations in dietary sodium intake.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aldosterone / blood*
  • Atrial Natriuretic Factor / blood*
  • Blood Pressure / drug effects
  • Blood Proteins / analysis
  • Creatinine / blood
  • Diuresis / drug effects
  • Female
  • Humans
  • Kinetics
  • Male
  • Potassium / blood
  • Potassium / urine
  • Renin / blood*
  • Sodium / blood
  • Sodium, Dietary / pharmacology*

Substances

  • Blood Proteins
  • Sodium, Dietary
  • Aldosterone
  • Atrial Natriuretic Factor
  • Sodium
  • Creatinine
  • Renin
  • Potassium