Nonoperative management of full-thickness intravenous extravasation injuries in premature neonates using enzymatic debridement

Ann Plast Surg. 1989 Feb;22(2):146-9. doi: 10.1097/00000637-198902000-00010.


Peripheral intravenous fluid extravasation is a common occurrence among neonatal intensive care unit patients. Fifteen high-risk neonates, averaging less than 35 weeks' gestation and less than 1,500 g birth weight, with full-thickness extravasation injuries were successfully treated nonoperatively by a topical fibrinolysin/deoxyribonuclease ointment. All wounds healed without delaying hospital discharge, and no significant scar contractures were observed in patients followed up to 16 months after injury.

MeSH terms

  • Administration, Topical
  • Debridement
  • Deoxyribonucleases / therapeutic use*
  • Drug Combinations / therapeutic use
  • Extravasation of Diagnostic and Therapeutic Materials / drug therapy
  • Extravasation of Diagnostic and Therapeutic Materials / therapy*
  • Female
  • Fibrinolysin / therapeutic use*
  • Humans
  • Infant, Newborn
  • Infant, Premature, Diseases / drug therapy
  • Infant, Premature, Diseases / therapy*
  • Male
  • Ointments


  • Drug Combinations
  • Ointments
  • deoxyribonuclease, plasmin drug combination
  • Deoxyribonucleases
  • Fibrinolysin