Burned to the bone

Sci Transl Med. 2014 Sep 24;6(255):255fs37. doi: 10.1126/scitranslmed.3010168.

Abstract

Heterotopic ossification--a complication of severe burns, head or blast injuries, and orthopaedic trauma--can result from altered adenosine metabolism in mesenchymal stem cells in response to elevated extracellular ATP (Peterson et al., this issue).

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Achilles Tendon / drug effects*
  • Adenosine Triphosphate / metabolism*
  • Animals
  • Apyrase / pharmacology*
  • Burns / drug therapy*
  • Female
  • Humans
  • Male
  • Mesenchymal Stem Cells / drug effects*
  • Ossification, Heterotopic / drug therapy*
  • Osteogenesis / drug effects*

Substances

  • Adenosine Triphosphate
  • Apyrase