Transforming growth factors beta 1 and beta 2 as well as milk growth factor decrease anti-CD3-induced proliferation of human lymphocytes without inhibiting the anti-CD3-mediated increase of [Ca2+]i and the activation of protein kinase C

FEBS Lett. 1989 Jun 5;249(2):289-92. doi: 10.1016/0014-5793(89)80643-x.

Abstract

Porcine transforming growth factor 1 and 2 (pTGF-beta 1 and -beta 2) and milk growth factor (MGF) at 1 ng/ml significantly inhibited the proliferation of human lymphocytes induced by anti-CD3 antibodies. In contrast, the anti-CD3-mediated increase of intracellular Ca2+ and the activation and translocation of protein kinase C were not affected by the transforming growth factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Differentiation, T-Lymphocyte / immunology*
  • Biological Factors / pharmacology*
  • CD3 Complex
  • Calcium / metabolism*
  • Enzyme Activation
  • Humans
  • Protein Kinase C / metabolism*
  • Receptors, Antigen, T-Cell / immunology*
  • Swine
  • T-Lymphocytes / immunology*
  • Transforming Growth Factors / pharmacology*

Substances

  • Antigens, Differentiation, T-Lymphocyte
  • Biological Factors
  • CD3 Complex
  • Receptors, Antigen, T-Cell
  • Transforming Growth Factors
  • Protein Kinase C
  • Calcium