Predictors of thrombosis in hepatic vasculature during microwave tumor ablation of an in vivo porcine model

Abstract

Purpose: To evaluate and model the risk of in vivo thrombosis in each hepatic vessel type during hepatic microwave ablation as a function of vessel diameter, velocity, and vessel-antenna spacing.

Materials and methods: A single microwave ablation antenna was inserted into a single porcine lobe (n = 15 total) adjacent to a hepatic artery, hepatic vein, or portal vein branch. Conventional ultrasound and Doppler ultrasound were used to measure the vessel diameter, blood flow velocity, and vessel-antenna spacing. A microwave ablation zone was created at 100 W for 5 minutes. Thrombus formation was evaluated on ultrasound performed immediately after the procedure. Logistic regression was used to evaluate the predictive value of vessel diameter, blood flow velocity, and vessel-antenna spacing on vascular thrombosis.

Results: Thrombosis was identified in 53% of portal veins, 13% of hepatic veins, and 0% of hepatic arteries. The average peak blood flow rate of the hepatic artery was significantly greater than the average peak blood flow rate of the hepatic vein and portal vein. Peak blood flow velocity < 12.45 cm/s, vessel diameter < 5.10 mm, and vessel-antenna spacing < 3.75 mm were strong predictors of hepatic vein thrombosis. However, these individual factors were not predictive of the more common portal vein thrombosis.

Conclusions: Hepatic arteries do not appear to be at risk for thrombosis during microwave ablation procedures. Portal vein thrombosis was more common than hepatic vein thrombosis during microwave ablation treatments but was not as predictable based on vessel diameter, flow velocity, or vessel-antenna spacing alone.

Keywords: ROC; receiver operator characteristic.