Mania induced by lorazepam withdrawal: a report of two cases

J Affect Disord. 1989 Jul-Aug;17(1):93-5. doi: 10.1016/0165-0327(89)90028-1.


Although depression is a well recognised component of the benzodiazepine withdrawal syndrome there have, as yet, been no convincing reports of mania. We report two cases of mania induced by abrupt discontinuation of lorazepam. Both cases were treated by reintroduction of the benzodiazepine followed by gradual dose reduction.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anxiety Disorders / drug therapy
  • Bipolar Disorder / chemically induced*
  • Delusions / chemically induced
  • Humans
  • Lorazepam / adverse effects*
  • Lorazepam / therapeutic use
  • Male
  • Paranoid Disorders / chemically induced
  • Substance Withdrawal Syndrome / etiology*


  • Lorazepam