Protein tyrosine phosphatase regulation of stem and progenitor cell biology

Veronique Dubreuil; Jan Sap; Sheila Harroch

doi:10.1016/j.semcdb.2014.09.012

Protein tyrosine phosphatase regulation of stem and progenitor cell biology

Semin Cell Dev Biol. 2015 Jan:37:82-9. doi: 10.1016/j.semcdb.2014.09.012. Epub 2014 Sep 26.

Authors

Veronique Dubreuil¹, Jan Sap², Sheila Harroch³

Affiliations

¹ University of Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216, CNRS, Paris, France.
² University of Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216, CNRS, Paris, France. Electronic address: jan.sap@univ-paris-diderot.fr.
³ Institut Pasteur, Department of Neuroscience, Paris, France. Electronic address: sheila.harroch@pasteur.fr.

PMID: 25256403
DOI: 10.1016/j.semcdb.2014.09.012

Abstract

This review surveys the contributions of protein tyrosine phosphatases (PTPs) to maintenance and differentiation of stem and progenitor cells. A diverse family of PTPs acts at multiple steps of signaling cascades and cellular locales. Their activities as signaling modifiers provide another layer of integration of signaling pathways, which functionally link to the cellular activity and ultimately converge into the regulation of stem and progenitor cell fates. The development of agents targeting PTPs is a growing endeavor that will benefit stem cell biology and offer promising therapeutic strategies.

Keywords: Signaling; Stem cells; Tyrosine phosphatases.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adult Stem Cells / metabolism
Animals
Cell Differentiation
Cell Proliferation
Humans
Pluripotent Stem Cells / metabolism
Protein Tyrosine Phosphatases / metabolism*
Signal Transduction
Stem Cells / cytology*
Stem Cells / metabolism*

Substances

Protein Tyrosine Phosphatases