Factors influencing the response to hepatitis B vaccination of hemodialysis patients

Nephron. 1989;51(4):474-7. doi: 10.1159/000185379.

Abstract

The response rate and HBsAG antibody concentrations were examined after hepatitis B vaccination in 78 hemodialysis patients aged between 29 and 79 years. The values were related to age, duration of hemodialysis, body weight, creatinine, urea nitrogen, serum concentrations of beta 2-microglobulin and soluble interleukin-2 receptor (IL-2R). Patients with low anti-HBsAG antibody concentrations (10-100 mU/ml) had significantly higher IL-2R serum concentrations than those with high anti-HBsAG antibody concentrations (greater than 3,000 mU/ml; p less than 0.05). Discriminant multivariate analysis (p = 0.032) revealed the influence (62%) of IL-2R on the response rate while other factors were similar in all patient groups. It is concluded that preactivation of T cells with an increased release of IL-2R may contribute to impaired immune response after hepatitis B vaccination.

MeSH terms

  • Adult
  • Aged
  • Hepatitis B / prevention & control*
  • Hepatitis B Antibodies / analysis*
  • Hepatitis B Surface Antigens / immunology*
  • Hepatitis B Vaccines
  • Humans
  • Kidney Diseases / immunology
  • Middle Aged
  • Receptors, Interleukin-2 / analysis*
  • Renal Dialysis*
  • T-Lymphocytes / immunology
  • Viral Hepatitis Vaccines*

Substances

  • Hepatitis B Antibodies
  • Hepatitis B Surface Antigens
  • Hepatitis B Vaccines
  • Receptors, Interleukin-2
  • Viral Hepatitis Vaccines