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Review
, 60 (2), 299-312

The Economic and Quality-Of-Life Burden of Crohn's Disease in Europe and the United States, 2000 to 2013: A Systematic Review

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Review

The Economic and Quality-Of-Life Burden of Crohn's Disease in Europe and the United States, 2000 to 2013: A Systematic Review

David N Floyd et al. Dig Dis Sci.

Abstract

Background: Crohn's disease (CD) is associated with a substantial healthcare burden that affects the patient, healthcare systems and society in general.

Aim: To provide a systematic evaluation of published data relating to the economic and health-related quality-of-life (HRQoL) burden of CD in selected European countries (Germany, France, UK, Italy, Spain) and the USA since 2000.

Methods: We undertook a systematic review of publications relating to CD, its economic burden and impact on HRQoL. Research questions focused on the disease costs from a societal perspective and HRQoL burden in adults and pediatric/adolescent patients according to disease stage/severity. Total, direct and indirect costs were identified, as well as the impact of CD on HRQoL measured using both generic and disease-specific instruments.

Results: Overall, 61 publications met the research criteria (38 on costs, 23 on HRQoL). CD in the USA and Europe together was associated with annual total costs of nearly <euro>30 billion, more than half due to indirect costs. HRQoL was consistently and statistically significantly lower among CD patients compared with normal populations, due to physical, emotional and social effects.

Conclusions: CD is a global health problem with high societal costs and substantial HRQoL burden. High-value care pathways including cost-effective therapies will help to induce and maintain remission, reduce complications of disease and improve HRQoL.

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References

    1. J Crohns Colitis. 2012 Feb;6 Suppl 2:S224-34 - PubMed
    1. Inflamm Bowel Dis. 2009 Jan;15(1):47-55 - PubMed
    1. JAMA. 2013 May 22;309(20):2150-8 - PubMed
    1. Adv Ther. 2012 Jul;29(7):620-34 - PubMed
    1. Colorectal Dis. 2005 Jul;7(4):375-81 - PubMed

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