ALT telomeres borrow from meiosis to get moving

Cell. 2014 Sep 25;159(1):11-12. doi: 10.1016/j.cell.2014.09.013.


Telomere clustering is required for the homologous recombination events that maintain chromosome ends in cells relying on alternative lengthening of telomeres (ALT). New data demonstrate that damage signaling at telomeres, a likely step in activating maintenance mechanisms, induces directional movement and synapsis driven by the machinery responsible for recombination in meiosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Chromosome Pairing*
  • Humans
  • Recombination, Genetic*
  • Telomere / metabolism*