ALT telomeres borrow from meiosis to get moving

Cell. 2014 Sep 25;159(1):11-12. doi: 10.1016/j.cell.2014.09.013.

Abstract

Telomere clustering is required for the homologous recombination events that maintain chromosome ends in cells relying on alternative lengthening of telomeres (ALT). New data demonstrate that damage signaling at telomeres, a likely step in activating maintenance mechanisms, induces directional movement and synapsis driven by the machinery responsible for recombination in meiosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Chromosome Pairing*
  • Humans
  • Recombination, Genetic*
  • Telomere / metabolism*