Improvement in skin wrinkles using a preparation containing human growth factors and hyaluronic acid serum

J Cosmet Laser Ther. 2015 Feb;17(1):20-3. doi: 10.3109/14764172.2014.968577. Epub 2014 Oct 27.

Abstract

Background: Skin aging is accompanied by wrinkle formation. At some sites, such as the periorbital skin, this is a relatively early phenomenon.

Objective: We evaluated the anti-wrinkle effect of a preparation containing human growth factor and hyaluronic acid serum on periorbital wrinkles (crow's feet).

Materials and methods: In total, 23 Korean women (age range: 39-59 years), who were not pregnant, nursing, or undergoing any concurrent therapy, were enrolled in this study. All the patients completed an 8-week trial of twice-daily application of human growth factor and hyaluronic acid serum on the entire face. Efficacy was based on a global photodamage score, photographs, and image analysis using replicas and visiometer analysis every 4 weeks. The standard wrinkle and roughness parameters used in assessing skin by visiometer were calculated and statistically analyzed.

Results: Periorbital wrinkles were significantly improved after treatment, with improvements noted both by physician's assessment and visiometer analysis.

Conclusion: Topical application of human growth factor and hyaluronic acid was beneficial in reducing periorbital wrinkles.

Keywords: human growth factor; hyaluronic acid; wrinkle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Adult
  • Dermatologic Agents / therapeutic use*
  • Drug Combinations
  • Epidermal Growth Factor / therapeutic use
  • Female
  • Fibroblast Growth Factor 10 / therapeutic use
  • Fibroblast Growth Factor 2 / therapeutic use
  • Humans
  • Hyaluronic Acid / therapeutic use*
  • Insulin-Like Growth Factor I / therapeutic use
  • Intercellular Signaling Peptides and Proteins / therapeutic use*
  • Middle Aged
  • Skin Aging / drug effects*

Substances

  • Dermatologic Agents
  • Drug Combinations
  • FGF10 protein, human
  • Fibroblast Growth Factor 10
  • Intercellular Signaling Peptides and Proteins
  • Fibroblast Growth Factor 2
  • Epidermal Growth Factor
  • Insulin-Like Growth Factor I
  • Hyaluronic Acid