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, 17 (2), 102-8

Adverse Reactions to Injectable Soft Tissue Fillers: Memorable Cases and Their Clinico-Pathological Overview

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Adverse Reactions to Injectable Soft Tissue Fillers: Memorable Cases and Their Clinico-Pathological Overview

Soo-Keun Lee et al. J Cosmet Laser Ther.

Abstract

Background: Filler injection is a minimally invasive procedure widely used for soft tissue augmentation. Although the safety profile is favorable, adverse events can occur, especially after illegal filler injection.

Objectives: The authors present memorable cases of filler complications and review their clinico-pathological features and treatment strategies.

Patients and methods: This is a retrospective, single-center case series. The authors identified eight patients with significant complications following filler injection. A medical record review was performed for clinical history, histopathological studies, and treatment.

Results: Six female and two male subjects presented with significant filler complications. The time interval between filler injection and the development of a complication varied greatly among cases (immediately afterwards to 14 years following filler injection). Four of the patients received illegal filler injection where the injected material was either unknown (25%) or was told as paraffin (12.5%) or Vaseline(®) (12.5%). Hyaluronic acid fillers were used in two patients (25%) and the rest were injected with porcine atelocollagen (12.5%) and polyacrylamide hydrogel (12.5%). The complications were classified as an allergic reaction (25%), filler material migration (12.5%), injection necrosis + embolism (25%), and foreign body granuloma (37.5%), based on their clinico-pathological features and were treated accordingly.

Conclusion: Adverse effects are not uncommon following filler injection. Physicians should be aware of the potential side effects, recognize their presentations, and understand how to manage them.

Keywords: adverse reactions; memorable cases; soft tissue fillers.

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